Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study

Paola Sacerdote; Barbara Manfredi; Paolo Mantegazza

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Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study

机译：阿片类药物的抗伤害感受和免疫抑制作用：与结构有关的活性研究

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Molecules that carry modifications of C_6, the C_7_8 bond and C_14 together with an allyl or caboxymethyl group on the piperidinic ring antagonized both the antinociceptive and the immunosuppressive effect of opiates and were themselves immunostimulants.

机译：带有C_6，C_7_8键和C_14修饰基团的分子与哌啶环上的烯丙基或卡巴氧甲基一起拮抗阿片类药物的镇痛作用和免疫抑制作用，它们本身就是免疫刺激剂。

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《British Journal of Pharmacology》 |1997年第4期|p.834-840|共7页
作者
Paola Sacerdote; Barbara Manfredi; Paolo Mantegazza;
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作者单位

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Morphine; codeine; oxycodone;

机译：吗啡;可待因羟考酮;

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1. Antinociceptive Activity of a Novel Non-Steroidal Anti-Inflammatory Drug (M-5011) with Low Ulcerogenic Effects in Mice [J] . Hiroshi Takase, Kazumi Iwata, Naofumi Murakami, Japanese Journal of Pharmacology . 1996,第1期

机译：新型的非甾体类抗炎药（M-5011）具有低致溃疡作用，对小鼠具有一定的镇痛作用
2. The effects of drugs with immunosuppressive or immunomodulatory activities on xenobiotics-metabolizing enzymes expression in primary human hepatocytes [J] . Vrzal Radim, Zenata Ondrej, Bachleda Petr, Toxicology in vitro: an international journal published in association with BIBRA . 2015,第5期

机译：具有免疫抑制或免疫调节活性的药物对人原代肝细胞异种代谢酶表达的影响
3. Differential effects of immunosuppressive drugs on COX-2 activity in vitro and in kidney transplant patients in vivo [J] . Bente Jespersen123 Helle C. Thiesson1 Charlotte Henriksen2 Karina Therland2 Christel Falk1 Tina Poulsen4 Betina Fogh2 Kirsten Madsen2 Steen Walther5 and Boye L. Jensen2 Nephrology Dialysis Transplantation . 2009,第5期

机译：免疫抑制药物对体外和体内肾移植患者COX-2活性的差异作用
4. Effects of Antiarrythmic Drug Lidocaine on Ventricular Electrical Activity. A Computer Modelling Study [C] . K. Cardona, J. Saiz, M. Monserrat, Annual Scientific Conference of Computers in Cardiology . 2005

机译：抗心律失常药物利用椰油在室性电活动中的影响。计算机建模研究
5. Running wheel activity attenuates the effects of exogenous opiates: Implications for the endogenous opioid system. [D] . Mathes, Wendy Foulds. 2000

机译：滚轮活动减弱了外源阿片的影响：对内源性阿片样物质系统的影响。
6. Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study [O] . Paola Sacerdote, Barbara Manfredi, Paolo Mantegazza, 1997

机译：阿片类药物的抗伤害感受和免疫抑制作用：与结构有关的活性研究
7. Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study [O] . Sacerdote, Paola, Manfredi, Barbara, Mantegazza, Paolo, 1997

机译：阿片类药物的抗伤害感受和免疫抑制作用：与结构有关的活性研究

Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study

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