Y-27632, an inhibitor of Rho-kinase, antagonizes noradrenergic contractions in the rabbit and human penile corpus cavernosum

摘要

We have examined the effect of an inhibitor of Rho-kinase,(+)-(R)-trans-1(1-aminoethyl)-N-(4- pyridyl)cyclohexanecarboxamide dihydrochloride monohydrate(Y-27632), on the contractions elicited by noradrenergic nerve stimulation and by phenylephrine in the human and rabbit penile corpus cavernosum. In both tissues, after treatment with scopolamine(100μM)and N~G-nitro-L- argine methyl ester(L-NAME; 300μM), electrical field stimulation(EFS)elicited noradrenergic contractions. These contractions were inhibited by Y-27632 in a concentration-dependent manner.