Reduction of opioid dependence by the CB_1 antagonist R141716A in mice: evaluation of the interest in pharmacotherapy of opioid addiction

摘要

Several compounds, mainly opioid agnoists such as methadone, are currently used for long term medication of heroin addicts. Nervertheless, these maintenance treatments have the disadvantage to induce a dependence to another opiate. As interactions between opoid and cannabinoid systems have been demonstrated, the ability of the CB_1 antagonist, SR141716A to reduce morphine-induced addiction was investigated. The effects of SR141716A on the rewarding responses of morphine were evaluated in the place Conditioning paradigm.