Effects of specific inhibition of cyclo-oxygenase-1 and cyclo-oxygenase-2 in the rat stomach with normal mucosa and after acid challenge

摘要

Effects of the cyclo-oxygenase(COX)-1 inhibitor SC-560 and the COX-2 inhibitors rofecoxib and DFU were investigated in the normal stomach and after acid challenge. In healthy rats, neither SC-560 nor rofecoxib(20 mg kg~-1 each)given alone damaged the Mucosa. Co-treatment with SC-560 and rofecoxib, however, induced severe lesions comaprable to Indomethacin(20 mg kg~-1)whereas co-administration of SC-560 and DFU(20 mg kg~-1 each)had No comparable ulcerogenic effect 5 after dosing. SC-560(20 mg kg~-1)inhibited gastric 6-keto-prostaglandin(PG)F_1αby 86±5/100 and platelet Thromboxane(TX)B_2 formation by 89±4/100 comparable to indomethacin(20 mg kg~-1).