Safety and efficacy of anti–tumor necrosis factor therapy in ten patients with recent-onset refractory reactive arthritis

摘要

There are few treatments for reactive arthritis (ReA). Since concentrations of tumor necrosis factor (TNF) are high in the serum and joints of patients with persistent ReA, this cytokine could be targeted in patients who do not respond to nonsteroidal antiinflammatory drugs (NSAIDs) and disease-modifying antirheumatic drugs (DMARDs). We undertook this study to investigate the safety and efficacy of TNF antagonists in patients with recent-onset and refractory ReA.