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首页> 外文期刊>Applied Physics Letters >Entropy-enthalpy compensation may be a useful interpretation tool for complex systems like protein-DNA complexes: An appeal to experimentalists
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Entropy-enthalpy compensation may be a useful interpretation tool for complex systems like protein-DNA complexes: An appeal to experimentalists

机译:熵焓补偿可能是蛋白质-DNA复合物等复杂系统的有用解释工具:对实验学家的吸引力

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摘要

In various chemical systems, enthalpy-entropy compensation (EEC) is a well-known rule of behavior, although the physical roots of it are still not completely understood. It has been frequently questioned whether EEC is a truly physical phenomenon or a coincidence due to trivial mathematical connections between statistical-mechanical parameters-or even simpler: A phantom effect resulting from the misinterpretation of experimental data. Here, we review EEC from another standpoint using the notion of correlation, which is essential for the method of factor analysis but is not conventional in physics and chemistry. We conclude that the EEC may be rationalized in terms of hidden (not directly measurable with the help of the current experimental set-up) but physically real factors, implying a Carnot-cycle model in which a micro-phase transition (MPT) plays a crucial role. Examples of such MPTs underlying physically valid EEC should be typically cooperative processes in supramolecular aggregates, like changes of structured water at hydrophobic surfaces, conformational transitions upon ligand-biopolymer binding, and so on. The MPT notion could help rationalize the occurrence of EEC in connection with hydration and folding of proteins, enzymatic reactions, functioning of molecular motors, DNA de- and rehybridization, as well as similar phenomena.
机译:在各种化学系统中,焓-熵补偿(EEC)是一种众所周知的行为准则,尽管其物理根源仍未被完全理解。人们经常质疑EEC是真正的物理现象,还是由于统计力学参数之间的琐碎数学联系而产生的巧合,甚至更简单:由于对实验数据的误解而产生的幻像效应。在这里,我们从另一个角度使用相关性的概念来回顾EEC,相关性对于因子分析方法是必不可少的,但在物理和化学领域却并非常规。我们得出的结论是,EEC可能在隐藏方面(不能通过当前的实验设置直接测量)合理化,但在物理上是真实因素,这意味着卡诺循环模型中的微相变(MPT)起着重要作用。关键的角色。这种在物理上有效的EEC基础上的MPT的例子通常应该是超分子聚集体中的协同过程,例如疏水表面上结构化水的变化,配体与生物聚合物结合后的构象转变等。 MPT概念可以帮助合理化与蛋白质的水合和折叠,酶促反应,分子马达的功能,DNA脱杂交和再杂交以及类似现象有关的EEC的发生。

著录项

  • 来源
    《Applied Physics Letters》 |2012年第19期|p.193701.1-193701.4|共4页
  • 作者

    E. B. Starikov; B. Norden;

  • 作者单位

    Institute for Materials Science and Max Bergmann Center of Biomaterials, Dresden University of Technology,D-01062 Dresden, Germany,Department of Physical Chemistry, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden;

    Department of Physical Chemistry, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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