Transition metal complexes of 1,2-dihydroquinazolinone derivative, an emerging class of analgesic and anti-inflammatory agents

摘要

A new 1,2-dihydroquinazolinone, 2-(2-hydroxy-phenyl)-3-[1-(2-oxo-2H-chromen-3-yl)-ethylideneamino]-2,3-dihydro-1H-quinazolin-4-one (L) and its Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes have been prepared. These were characterized by elemental, spectral [UV–visible, IR, NMR (1H, 13C and 2D heteronuclear correlation) and mass], conductance, magnetic susceptibility and thermal studies. The physicochemical data indicate that the ligand behaves as tridentate with ONO donor sequence towards the metal ions, and trigonal bipyramidal geometry was assigned for complexes. The ligand and its metal complexes were evaluated for their in vivo anti-inflammatory and analgesic activity. The tested compounds have shown excellent activity, which are almost equipotent to the standard used in the study. Copyright ? 2011 John Wiley & Sons, Ltd.