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Diagnostics and treatment of nerve agent poisoning-current status and future developments

机译:神经代理中毒的诊断和治疗 - 现状和未来发展

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摘要

Although 193 states have committed to the Chemical Weapons Convention and 98% of the declared chemical weapons stockpiles have been destroyed so far, nerve agent poisoning remains a lingering threat. The recent dissemination of sarin in Syria, the assassination of Kim Jong-Nam in Malaysia, and the assault on Sergei Skripal in the United Kingdom underline the need for effective treatment. The current therapeutic options of a muscarinic receptor antagonist, an oxime, and an anticonvulsant have been unchanged for decades. Therefore, new therapeutic strategies, for example, bio scavengers and receptor-active substances, are promising concepts that have to be examined for their benefits and limitations. In order to facilitate rapid diagnosis in challenging clinical situations, point-of-care diagnostics and detection are of importance. Therapeutic guidance concerning the duration and success of the current oxime therapy via determination of the cholinesterase status can contribute to an optimal use of resources. In summary, the challenges of current and future therapies for nerve agent poisoning and key diagnostic devices will be discussed.
机译:虽然193个国家致力于化学武器公约,但迄今为止,98%的宣布的化学武器库存已经被摧毁,神经药物中毒仍然是一个挥之不去的威胁。最近在叙利亚的Sarin传播,在马来西亚暗杀Kim Jong-Nam,以及在英国的Sergei Skripal的攻击强调了有效治疗的必要性。几十年来,毒蕈碱受体拮抗剂,肟和抗惊厥药的目前的治疗方法已经保持不变。因此,新的治疗策略,例如生物清除剂和受体活性物质,是必须审查其利益和局限性的承诺概念。为了促进挑战性临床情况的快速诊断,护理点诊断和检测具有重要性。通过测定胆碱酯酶状态的当前肟治疗的持续时间和成功的治疗指南可以有助于最佳利用资源。总之,将讨论神经代理中毒和关键诊断装置的当前和未来疗法的挑战。

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