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首页> 外文期刊>Annals of the New York Academy of Sciences >How copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1
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How copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1

机译:铜如何穿过哺乳动物铜转运蛋白1(Ctr1)穿过细胞膜

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摘要

The copper transporter 1, Ctr1, is part of a major pathway for cellular copper (Cu) uptake in the intestinal epithelium, in hepatic and cardiac tissue, and likely in many other mammalian cells and tissues. Here, we summarize what is currently known about how extracellular Cu travels across the plasma membrane to enter the cytoplasm for intracellular distribution and for use by proteins and enzymes, the physiological roles of Ctr1, and its regulation. As a critical Cu importer, Ctr1 occupies a strategic position to exert a strong modifying influence on diseases and pathophysiological states caused by imbalances in Cu homeostasis. A more thorough understanding of the mechanisms that regulate Ctrl abundance, trafficking, and function will provide new insights and opportunities for disease therapies.
机译:铜转运蛋白1(Ctr1)是肠上皮细胞,肝和心脏组织以及许多其他哺乳动物细胞和组织中细胞铜(Cu)吸收的主要途径的一部分。在这里,我们总结了目前有关细胞外铜如何穿越质膜进入细胞质以进行细胞内分布以及被蛋白质和酶使用,Ctr1的生理作用及其调控的已知知识。作为重要的铜进口国,Ctr1占据着战略地位,可对因铜稳态失衡而引起的疾病和病理生理状态产生强大的影响。对调节Ctrl丰度,贩运和功能的机制的更透彻的了解将为疾病治疗提供新的见识和机会。

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