A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes

A. Yada1 M. Yazawa2 S. Ishida1 H. Yoshida2 K. Ichikawa2 S. Kurakata3 and K. Fujiwara1

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A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes

机译：新型人源化抗人类死亡受体5抗体CS-1008诱导肿瘤细胞凋亡，而对肝细胞无毒性

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Background: The antitumor activity of CS-1008, a humanized agonistic anti-human death receptor (DR) 5 antibody, was investigated in preclinical models.

机译：背景：在临床前模型中研究了CS-1008（一种人源化抗人死亡受体（DR）5抗体）的抗肿瘤活性。

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来源
《Annals of Oncology》 |2008年第6期|1060-1067|共8页
作者
A. Yada1 M. Yazawa2 S. Ishida1 H. Yoshida2 K. Ichikawa2 S. Kurakata3 and K. Fujiwara1;
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作者单位

Biological Research Laboratories IV;

Advanced Technology Research Laboratories;

Biological Research Laboratories III Daiichi Sankyo Co. Ltd. Tokyo Japan;

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原文格式 PDF
正文语种 eng
中图分类
关键词
apoptosis, combination therapy, death receptor 5, humanized antibody;

机译：细胞凋亡;联合治疗;死亡受体5;人源化抗体;

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1. A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes. [J] . Yada A, Yazawa M, Ishida S, Annals of oncology: official journal of the European Society for Medical Oncology . 2008,第6期

机译：新型人源化抗人类死亡受体5抗体CS-1008诱导肿瘤细胞凋亡，而对肝细胞无毒性。
2. Thirteen-week Intravenous Toxicity Study of a Novel Humanized Anti-Human Death Receptor 5 Monoclonal Antibody, CS-1008, in Cynomolgus Monkeys [J] . Tomofumi Kimotsuki, Kohji Tanaka, Tomomi Sugiura, Journal of Toxicologic Pathology . 2010,第1期

机译：新型人源化抗人类死亡受体5单克隆抗体CS-1008在食蟹猴中的十三周静脉毒性研究。
3. A novel agonistic anti-human death receptor 5 monoclonal antibody with tumoricidal activity induces caspase- and mitochondrial-dependent apoptosis in human leukemia Jurkat cells. [J] . Du YW, Chen JG, Bai HL, Cancer biotherapy and radiopharmaceuticals . 2011,第2期

机译：具有肿瘤活性的新型激动性抗人死亡受体5单克隆抗体可诱导人白血病Jurkat细胞中caspase和线粒体依赖性细胞凋亡。
4. TRAIL (TNF-Related Apoptosis-Inducing Ligand) Induces Necrosis-Like Cell Death in Tumor Cells at Acidic Extracellular pH [C] . OLIVIER MEURETTE, LAURENCE HUC, AMELIE REBILLARD, International Conference on Natural Products and Molecular Medicine . 2005

机译：TRAIL（与TNF相关的凋亡诱导配体）在酸性细胞外pH下诱导肿瘤细胞中的坏死状细胞死亡
5. Involvement of TRAIL death receptors in human tumorigenesis and mechanisms of TRAIL-induced apoptosis signaling. [D] . Ozoren, Nesrin. 2002

机译：TRAIL死亡受体参与人类肿瘤发生和TRAIL诱导的细胞凋亡信号传导机制。
6. Thirteen-week Intravenous Toxicity Study of a Novel Humanized Anti-Human Death Receptor 5 Monoclonal Antibody CS-1008 in Cynomolgus Monkeys [O] . Tomofumi Kimotsuki, Kohji Tanaka, Tomomi Sugiura, 2010

机译：新型人源化药物的十三周静脉毒性研究食蟹猴中的抗人类死亡受体5单克隆抗体CS-1008 猴子
7. Thirteen-week Intravenous Toxicity Study of a Novel Humanized Anti-Human Death Receptor 5 Monoclonal Antibody, CS-1008, in Cynomolgus Monkeys [O] . Kimotsuki, Tomofumi, Tanaka, Kohji, Sugiura, Tomomi, 2010

机译：新型人源化药物的十三周静脉毒性研究食蟹猴中的抗人类死亡受体5单克隆抗体CS-1008 猴子

A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes

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