Study of the PPRV Protein Protein interaction study: mapping the phosphoprotein (P) binding site on the nucleoprotein (N).

摘要

In 2003, the APHL embarked on an EC and Wellcome Trust supported collaborative project to develop a PPR marker vaccine. Within that project, APHL was in charge of studying the virus protein-protein interactions to identify on the nucleoprotcin (N) zone (s) not essential for the virus to be used as the marker insertion site and also for the development of the marker vaccine companion test. In previous Newsletters, we reported on the results generated by the nucleoprotcin mapping study by identifying the N-N interaction sites and also the binding site of the matrix protein (M) and the phosphoprotein (P) onto N.