Bias in Association between FEV_1/FVC% Predicted at 7 Years and Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome

摘要

We were interested to read the article by Bui and colleagues in which the authors tried to evaluate the associations between childhood lung function and current asthma, spirometrically defined chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap syndrome (ACOS) (1) [this issue, pp. 39-46]. The results have demonstrated that FEV_1/FVC ratio at 7 years can be a predictor of both COPD alone (odds ratio [OR], 5.76; 95% confidence interval [CI], 1.9-17.4) and ACOS (OR, 16.3; 95% CI, 4.7-55.9) (1).