Body Mass Index, Height, and Risk of Lymphatic Malignancies: A Prospective Cohort Study

摘要

The association among body mass index (BMI), height, and the risk of lymphatic malignancies was investigatednin the Netherlands Cohort Study. The participants (n ¼ 120,852), Dutch men and women aged 55–69 years,ncompleted a self-administered questionnaire at baseline in 1986. After 13.3 years of follow-up, data on 1,042nlymphatic malignancy cases (including diffuse large-cell lymphoma, chronic lymphocytic leukemia, multiple mye-nloma, and other subtypes) and 4,588 subcohort members were available. Incidence rate ratios were estimated bynusing Cox regression models. BMI at baseline and BMI change since the age of 20 years were not associated withnlymphatic malignancy risk. However, the rate ratio of lymphatic malignancies per 4-unit increase in BMI at 20 yearsnof age was 1.13 (95% confidence interval (CI): 1.01, 1.25). The rate ratio of lymphatic malignancies per 5-cmnincrease in height was 1.08 (95%CI: 1.02, 1.15). For diffuse large-cell lymphoma, follicular lymphoma, and chronicnlymphocytic leukemia, the relative risks were 1.19 (95% CI: 1.07, 1.33), 1.15 (95% CI: 0.95, 1.40), and 1.09 (95%nCI: 0.95, 1.26), respectively, for each 5-cm increase in height. The positive associations among BMI at 20 years ofnage, height, and the risk of lymphatic malignancies suggest that exposures during early life play a role in thenetiology of lymphatic malignancies.