Biological function analysis of mice lacking a glycogene which synthesizes polylactosamine chains

摘要

Over the past few years, we have been isolating and characterizing many glycogenes including glycosyltransferases. We are attempting to elucidate the function of carbohydrate chains (glycoconjugates). We analyzed glycogene (especially glycosyltransferase)-deficient mice to investigate in vivo function of carbohydrate chains. In order to generate many strains of glycogene-deficient mice, we selected the target genes which are thought to be disease-related and biologically important.