Controlling Cell Adhesion to Titanium: Functionalization of Poly[oligo(ethylene glycol)methacrylate] Brushes with Cell-Adhesive Peptides

摘要

We present an approach to modify poly(OEGMA) brashes on titanium with peptide sequences from adhesion proteins to provide control over the adhesion of cells to the surfaces. The poly(OEGMA) brushes are stable, protein-adsorption- and cell-adhesion-resistant surfaces. Functionalization with bioadhesive peptides selectively promotes cell adhesion. This approach provides a robust methodology to generate coatings that present controlled densities of bioactive ligands within a nonfouling background on metal substrates. This represents a biomolecular strategy to impart biofunctionality to biomedical-grade titanium and thereby enhance the biological performance and osseointe-gration of titanium-based orthopedic and dental devices.