Hypoxic preconditioning upregulates K_ATP channels through activation of protein kinase C in rat ventricular myocytes

摘要

At 0 mV and 5 min after 2, 4-dini- trophenol(DNP)perfusion, the membrane currents for the CON, HPC, PMA, and CH+ HPC were (3.5± 1.9),(7.7±1.5),(7.5±3.3),(4.6±2.4)nA, re- spectively. Compared with the CON, the Ik_ATP in the HPC and PMA were significantly augmented (P < 0.01) While the Ik_ATP in the CH+HPC remained similar to the CON( P < 0.05). 1) hypoxic pre- conditioning stimulated the activity of PKC and markedly enhanced the activity of K_ATP channels in the isolated rat cardiac myocotes; 2)PKC activation was involved in the upregulation of K_ATP channels.