17-β-Estradiol inhibits carotid sinus baroreceptor activity in anesthetized male rats

摘要

E_2 3, 10, and 30 μmol/L shifted FCCB to the right and downward, with a marked decrease in peak slope(PS)and peak interal valuse of carotid sinus nerve discharge(PIV)in a concen- tration-dependent manner, indicating the inhibitory effect of E_2 on CBA. Pretreatment with tamoxifen(TAM)10 μmol/L, and inhibitory of estrogen receptor, did not block the effect of E_2 on CBA. Preperfusion with L-NAME 100μmol/L, an inhibitor of NO synthase, could com- pletely abolish the effect of E_2 on CBA. NO donor SIN-1 10μmol/L could potentiate the inhibitory effect of E_2. E_2 inhibits CBA via endothelial NO release.