Effect of N-acetylcysteine and L-NAME on aluminium phosphide induced cardiovascular toxicity in rats

摘要

A1P caused significant hypotension, tachcar- dia, ECG abnormalities, and finally marked bradycardia. The mean survival time was(90±10)min. There was Significant increase in myocardial and glutathione peroxi- Dase(GSH Px)levels. NAC infusion(6025 mg.kg~-1. Min~-1, iv for 30 min)caused insignificant hemodynamic And biochemical changes. NAC increased the survival time by reducing myocardial Oxidative injury whereas L-NAME showed no such pro- Tective effects in rats exposed to A1P.