Design Synthesis and Antiviral Activity of Novel Ribonucleosides of 123‐Triazolylbenzyl‐aminophosphonates

摘要

A novel series of ribonucleosides of 1,2,3‐triazolylbenzyl‐aminophosphonates was synthesized through the Kabachnik–Fields reaction using I2 as catalyst followed by copper‐catalyzed cycloaddition of the azide–alkyne reaction (CuAAC). All structures of the newly prepared compounds were characterized by ¹H NMR, ¹³C NMR, and HRMS spectra. The structures of >2e, >2f, >3d, and >3g were further confirmed by X‐ray diffraction analysis. These compounds were tested against various strains of DNA and RNA viruses; compounds >4b and >4c showed a modest inhibitory activity against respiratory syncytial virus (RSV) and compound >4h displayed modest inhibitory activity against Coxsackie virus B4.