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The Influence of Drug Properties and Ontogeny of Transporters on Pediatric Renal Clearance through Glomerular Filtration and Active Secretion: a Simulation-Based Study

机译：基于肾小球滤过和主动分泌物的药物性质和转运子的形成对小儿肾脏清除的影响：基于模拟的研究

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摘要

The online version of this article (10.1208/s12248-020-00468-7) contains supplementary material, which is available to authorized users.

机译：本文的在线版本（10.1208 / s12248-020-00468-7）包含补充材料，可供授权用户使用。

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期刊名称 Springer Open Choice
作者
Sînziana Cristea; Elke Henriëtte Josephina Krekels; Amin Rostami-Hodjegan; Karel Allegaert; Catherijne Annette Jantine Knibbe;
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作者单位

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年(卷),期 -1(22),4
年度 -1
页码 -1
总页数 10
原文格式 PDF
正文语种
中图分类外科学;
关键词
active tubular secretion; glomerular filtration; ontogeny;

机译：肾小管主动分泌;肾小球滤过;个体发育;

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专利

1. Prediction of the Effects of Renal Impairment on Clearance for Organic Cation Drugs that Undergo Renal Secretion: A Simulation-Based Study [J] . Follman Kristin E., Morris Marilyn E. Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2018,第5期

机译：预测肾分泌有机阳离子药物清仓的影响：基于模拟的研究
2. Influence of glomerular filtration rate on the rate of para-aminohippurate secretion by the rat kidney: Micropuncture and clearance studies [J] . Dieter Haberle, A Ober and G Ruhland Kidney international. . 1975,第6期

机译：肾小球滤过率对大鼠肾脏对氨基马尿酸盐分泌速率的影响：微穿刺和清除研究
3. Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments. [J] . Kusuhara H, Watanabe T, Debori Y, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2011,第6期

机译：通过体外摄取实验预测阴离子药物的总体肾小管分泌和肝清除率以及涉及有机阴离子转运蛋白3的肾脏药物相互作用。
4. Measurement of glomerular filtration rate, renal plasma flow and endogenous creatinine clearance in cheetahs (Acinonyx jubatus jubatus) [C] . Erin Hall Holder, Scott B. Citino, Nancy Businga, Conference of the American Association of Zoo Veterinarians . 2001

机译：测量龟毛血管过滤速率，肾脏等离子体流动和内源性肌酐清除（Acinonyx Jubatus Jubatus）
5. Development and validation of an equation to predict glomerular filtration rate in Chinese: The renal formula in Chinese diabetes (RFCD) study. [D] . Leung, Tak Kei. 2007

机译：预测和预测中国人肾小球滤过率的方程式的开发和验证：中国糖尿病（RFCD）研究的肾脏公式。
6. Prediction of the Effects of Renal Impairment on Clearance for Organic Cation Drugs that Undergo Renal Secretion: A Simulation-Based Study [O] . Kristin E. Follman, Marilyn E. Morris -1

机译：基于模拟研究的肾功能不全对接受肾脏分泌的有机阳离子药物清除率的影响的预测
7. The Influence of Drug Properties and Ontogeny of Transporters on Pediatric Renal Clearance through Glomerular Filtration and Active Secretion: a Simulation-Based Study [O] . Sînziana Cristea, Elke Henriëtte Josephina Krekels, Amin Rostami-Hodjegan, 2020

机译：通过肾小球过滤和活性分泌的转运蛋白对转运蛋白对儿科肾间隙的影响：基于模拟的研究

The Influence of Drug Properties and Ontogeny of Transporters on Pediatric Renal Clearance through Glomerular Filtration and Active Secretion: a Simulation-Based Study

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