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Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue

机译：Ucp1增强子甲基化和染色质重塑在控制小鼠脂肪组织中Ucp1表达中的作用

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摘要

Aims/hypothesisIncreasing the expression of the brown adipose tissue-specific gene uncoupling protein-1 (Ucp1) is a potential target for treating obesity. We investigated the role of DNA methylation and histone modification in Ucp1 expression in adipose cell lines and ex vivo murine adipose tissues.

机译：目的/假设增加棕色脂肪组织特异性基因解偶联蛋白-1（Ucp1）的表达是治疗肥胖症的潜在目标。我们调查了DNA甲基化和组蛋白修饰在脂肪细胞系和离体鼠类脂肪组织中Ucp1表达中的作用。

著录项

期刊名称 Springer Open Choice
作者
A. Shore; A. Karamitri; P. Kemp; J. R. Speakman; M. A. Lomax;
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作者单位

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年(卷),期 -1(53),6
年度 -1
页码 1164–1173
总页数 10
原文格式 PDF
正文语种
中图分类外科学;
关键词
CpG dinucleotide Methylation Cyclic AMP response element Uncoupling protein-1 Adipose tissue;

机译：CpG二核苷酸;甲基化;环状AMP反应元件;蛋白1解偶联;脂肪组织;

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专利

1. Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue [J] . A. Shore, A. Karamitri, P. Kemp, Diabetologia . 2010,第6期

机译：Ucp1增强子甲基化和染色质重塑在控制小鼠脂肪组织中Ucp1表达中的作用
2. Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue [J] . A. Shore, A. Karamitri, P. Kemp, Diabetologia: clinical and experimental diabetes and metabolism . 2010,第6期

机译：Ucp1增强子甲基化和染色质重塑在控制小鼠脂肪组织中Ucp1表达中的作用
3. Oleuropein aglycone enhances UCP1 expression in brown adipose tissue in high-fat-diet-induced obese rats by activating beta-adrenergic signaling [J] . The Journal of Nutritional Biochemistry . 2017,第期

机译：通过激活β-肾上腺素能信号传导，Oleuropein糖苷酮增强了高脂饮食诱导的肥胖大鼠的棕色脂肪组织中的UCP1表达
4. CCAAT/Enhancer-Binding Protein Beta Controls Differentiation-Specific Expression of Chromatin Remodeling Factor BRM [C] . Toshinari Itoh, Katsuhide Miyake, Shinji Iijima Annual Meeting of the Japanese Association for Animal Cell Technology . 2009

机译：CCAAT / Enhancer结合蛋白β控制染色质重塑因子BRM的分化特异性表达
5. Control of Cardiac Gene Expression by Chromatin Architectural Proteins: Mechanisms at the Level of Chromatin Fiber, Transcriptome Remodeling and Cellular Phenotype. [D] . Monte, Emma Marie. 2015

机译：染色质建筑蛋白控制心脏基因表达：染色质纤维，转录组重塑和细胞表型水平的机制。
6. Browning and Beiging of Adipose Tissue Its Role in the Regulation of Energy Homeostasis and as a Potential Target for Alleviating Metabolic Diseases: Deletion of UCP1 enhances ex vivo aortic vasomotor function in female but not male mice despite similar susceptibility to metabolic dysfunction [O] . Nathan C. Winn, Zachary I. Grunewald, Michelle L. Gastecki, -1

机译：脂肪组织的褐变和变褐在能量稳态调节中的作用以及作为减轻代谢性疾病的潜在靶标：尽管对代谢功能障碍的敏感性相似但UCP1的缺失可增强雌性小鼠而非雄性小鼠的离体主动脉血管舒缩功能
7. Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue [O] . A. Shore, A. Karamitri, P. Kemp, 2010

机译：Ucp1增强子甲基化和染色质重塑在控制小鼠脂肪组织中Ucp1表达中的作用

Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue

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