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Cervical carcinoma-associated fibroblasts are DNA diploid and do not show evidence for somatic genetic alterations

机译：宫颈癌相关的成纤维细胞是DNA二倍体没有显示体细胞遗传改变的证据

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摘要

BackgroundCancer-associated fibroblasts (CAFs) have been recognized as important contributors to cancer development and progression. However, opposing evidence has been published whether CAFs, in addition to epigenetic, also undergo somatic genetic alterations and whether these changes contribute to carcinogenesis and tumour progression.

机译：背景技术与癌症相关的成纤维细胞（CAF）被认为是癌症发展和进展的重要因素。但是，已经发表了相反的证据，即CAFs除了表观遗传学之外，是否还会发生体细胞遗传改变，以及这些改变是否有助于癌变和肿瘤进展。

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期刊名称 Springer Open Choice
作者
Willem Ernst Corver; Natalja Tatjana ter Haar; Gert Jan Fleuren; Jan Oosting;
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作者单位

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年(卷),期 -1(34),6
年度 -1
页码 553–563
总页数 11
原文格式 PDF
正文语种
中图分类外科学;
关键词
Cervical cancer Formalin-fixed paraffin-embedded Carcinoma-associated fibroblast Vimentin Smooth-muscle actin Fluorescence activated cell sorter SNP-array;

机译：宫颈癌;福尔马林固定;石蜡包埋;癌相关成纤维细胞;波形蛋白;平滑肌肌动蛋白;荧光激活细胞分选仪;SNP阵列;

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专利

1. Cervical carcinoma-associated fibroblasts are DNA diploid and do not show evidence for somatic genetic alterations. [J] . Willem Ernst Corver, Natalja Tatjana Ter Haar, Gert Jan Fleuren, Cellular oncology . 2011,第6期

机译：宫颈癌相关的成纤维细胞是DNA二倍体，没有显示体细胞遗传改变的证据。
2. No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas [J] . Qiu W, Hu M, Sridhar A, Nature Genetics . 2008,第5期

机译：没有证据表明人类乳腺癌和卵巢癌的癌症相关成纤维细胞具有克隆性的体细胞遗传学改变
3. No evidence of somatic DNA copy number alterations in eutopic and ectopic endometrial tissue in endometriosis [J] . SaareM., S?ritsaD., VaidlaK., Human Reproduction . 2012,第6期

机译：没有证据表明子宫内膜异位症的异位和异位子宫内膜组织中的体细胞DNA拷贝数改变
4. Automated Wholeslide Analysis of Multiplex-Brightfield IHC Images for Cancer Cells and Carcinoma-Associated Fibroblasts [C] . Auranuch Lorsakul, Emilia Andersson, Suzana Vega Harring, Conference on image perception, observer performance, and technology assessment . 2017

机译：癌细胞和与癌相关的成纤维细胞的多-Brightfield IHC图像的自动全幻灯片分析
5. Regulation of senescence in human diploid fibroblasts: Alterations in gene expression and effects of serum factors [D] . Wistrom, Cheryl Lynn. 1991

机译：人类二倍体成纤维细胞衰老的调节：基因表达的变化和血清因子的影响
6. No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas [O] . Wen Qiu, Min Hu, Anita Sridhar, -1

机译：没有证据表明人类乳腺癌和卵巢癌的癌症相关成纤维细胞具有克隆性的体细胞遗传学改变
7. Cervical carcinoma-associated fibroblasts are DNA diploid and do not show evidence for somatic genetic alterations [O] . Willem Ernst Corver, Natalja Tatjana ter Haar, Gert Jan Fleuren, 2011

机译：宫颈癌相关的成纤维细胞是DNA二倍体，没有显示体细胞遗传改变的证据
8. Somatic Cell and Molecular Genetics Approach to DNA Repair and Mutagenesis [R] . Thompson, L. H. 1985

机译：体细胞和分子遗传学方法进行DNa修复和诱变

Cervical carcinoma-associated fibroblasts are DNA diploid and do not show evidence for somatic genetic alterations

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