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The primary cilium as a dual sensor of mechanochemical signals in chondrocytes

机译:初级纤毛作为软骨细胞中机械化学信号的双重传感器

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摘要

The primary cilium is an immotile, solitary, and microtubule-based structure that projects from cell surfaces into the extracellular environment. The primary cilium functions as a dual sensor, as mechanosensors and chemosensors. The primary cilia coordinate several essential cell signaling pathways that are mainly involved in cell division and differentiation. A primary cilium malfunction can result in several human diseases. Mechanical loading is sense by mechanosensitive cells in nearly all tissues and organs. With this sensation, the mechanical signal is further transduced into biochemical signals involving pathways such as Akt, PKA, FAK, ERK, and MAPK. In this review, we focus on the fundamental functional and structural features of primary cilia in chondrocytes and chondrogenic cells.
机译:初级纤毛是一种不动的,孤立的,基于微管的结构,从细胞表面伸入细胞外环境。初级纤毛充当机械传感器和化学传感器的双重传感器。初级纤毛协调了几种主要的细胞信号传导途径,这些途径主要参与细胞分裂和分化。纤毛原发性功能障碍可能导致多种人类疾病。机械负荷是几乎所有组织和器官中的机械敏感细胞所感觉到的。有了这种感觉,机械信号进一步转导为涉及诸如Akt,PKA,FAK,ERK和MAPK等途径的生化信号。在这篇综述中,我们关注软骨细胞和软骨细胞中原发纤毛的基本功能和结构特征。

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