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Pharmacokinetic Drug–Drug Interactions Between Vonoprazan and Low-Dose Aspirin or Nonsteroidal Anti-inflammatory Drugs: A Phase 2 Open-Label Study in Healthy Japanese Men

机译：Vonoprazan与低剂量阿司匹林或非甾体抗炎药之间的药代动力学药物相互作用：第二阶段开放标签健康日本男性研究

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BackgroundGastroprotective agents are recommended for patients receiving low-dose aspirin (LDA) or nonsteroidal anti-inflammatory drugs (NSAIDs). Vonoprazan is a potassium-competitive acid blocker recently approved for the prevention of peptic ulcer recurrence in patients receiving LDA or NSAIDs.

机译：背景胃肠道保护剂建议用于接受小剂量阿司匹林（LDA）或非甾体抗炎药（NSAIDs）的患者。 Vonoprazan是一种钾竞争性酸阻滞剂，最近被批准用于预防接受LDA或NSAID的患者的消化性溃疡复发。

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期刊名称 Springer Open Choice
作者
Yuuichi Sakurai; Madoka Shiino; Sayako Horii; Hiroyuki Okamoto; Koki Nakamura; Akira Nishimura; Yukikuni Sakata;
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作者单位

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年(卷),期 -1(37),1
年度 -1
页码 39–49
总页数 11
原文格式 PDF
正文语种
中图分类外科学;
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专利

1. Risk of peptic ulcer bleeding associated with Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs, low-dose aspirin, and antihypertensive drugs: A case-control study [J] . Nagata Naoyoshi, Niikura Ryota, Sekine Katsunori, Journal of gastroenterology and hepatology . 2015,第2期

机译：与幽门螺杆菌感染，非甾体类抗炎药，小剂量阿司匹林和降压药相关的消化性溃疡出血风险：病例对照研究
2. Impact of concomitant low-dose aspirin on the safety and tolerability of naproxen and esomeprazole magnesium delayed-release tablets in patients requiring chronic nonsteroidal anti-inflammatory drug therapy: An analysis from 5 Phase III studies [J] . AngiolilloD.J., DattoC., RainesS., Journal of thrombosis and thrombolysis . 2014,第1期

机译：低剂量阿司匹林对需要长期非甾体类抗炎药治疗的患者的萘普生和埃索美拉唑镁缓释片的安全性和耐受性的影响：来自五项III期研究的分析
3. Prediction of pharmacokinetic drug/drug interactions from In vitro data: interactions of the nonsteroidal anti-inflammatory drug lornoxicam with oral anticoagulants. [J] . Kohl C, Steinkellner M Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2000,第2期

机译：从体外数据预测药代动力学药物/药物相互作用：非甾体抗炎药氯诺昔康与口服抗凝剂的相互作用。
4. Rapid Determination of the Nonsteroidal Anti-inflammatory Drugs (NSAID) Paracetamol, Ibuprofen, Aspirin, Indomethacin and their Metabolites in Urine by On-line LC/LC-MS/MS [C] . H. Modick, G. Dierkes, T. Weiss, Annual conference of the International Society of Exposure Science . 2014

机译：在线LC / LC-MS / MS快速测定尿液中的非甾体抗炎药（扑热息痛），扑热息痛，布洛芬，阿司匹林，吲哚美辛及其代谢物
5. Herb-drug Interactions between Scutellariae Radix and Non-steroidal Anti-inflammatory Drugs: Pharmacokinetic and Pharmacodynamic Impact. [D] . Fong, Yui Kau. 2014

机译：黄cut与非甾体抗炎药之间的药草相互作用：药代动力学和药效学影响。
6. Use of low-dose aspirin and non-aspirin nonsteroidal anti-inflammatory drugs and risk of glioma: a case–control study [O] . D Gaist, L A García-Rodríguez, H T Sørensen, 2013

机译：小剂量阿司匹林和非阿司匹林非甾体类抗炎药的使用和胶质瘤的风险：病例对照研究
7. Pharmacokinetic Drug–Drug Interactions Between Vonoprazan and Low-Dose Aspirin or Nonsteroidal Anti-inflammatory Drugs: A Phase 2, Open-Label, Study in Healthy Japanese Men [O] . Yuuichi Sakurai, Madoka Shiino, Sayako Horii, 2016

机译：Vonoprazan与低剂量阿司匹林或非甾体抗炎药之间的药代动力学药物相互作用：第二阶段，开放标签，健康日本男性研究

Pharmacokinetic Drug–Drug Interactions Between Vonoprazan and Low-Dose Aspirin or Nonsteroidal Anti-inflammatory Drugs: A Phase 2 Open-Label Study in Healthy Japanese Men

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