Mice haploinsufficient for Map2k7 a gene involved in neurodevelopment and risk for schizophrenia show impaired attention a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline

摘要

RationaleMembers of the c-Jun N-terminal kinase (JNK) family of mitogen-activated protein (MAP) kinases, and the upstream kinase MKK7, have all been strongly linked with synaptic plasticity and with the development of the neocortex. However, the impact of disruption of this pathway on cognitive function is unclear.