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Pharmacokinetics and Tolerability of a Single Dose of Semaglutide a Human Glucagon-Like Peptide-1 Analog in Subjects With and Without Renal Impairment

机译：单剂量西马鲁肽（一种人胰高血糖素样肽-1类似物）在有或没有肾功能障碍的受试者中的药代动力学和耐受性

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摘要

BackgroundThe pharmacokinetics and tolerability of semaglutide, a once-weekly human glucagon-like peptide-1 analog in development for the treatment of type 2 diabetes mellitus, were investigated in subjects with/without renal impairment (RI).

机译：背景在有/无肾功能不全（RI）的受试者中研究了Semaglutide（一种每周一次的人类胰高血糖素样肽1类似物正在开发中，用于治疗2型糖尿病）的药代动力学和耐受性。

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期刊名称 Springer Open Choice
作者
Thomas C. Marbury; Anne Flint; Jacob B. Jacobsen; Julie Derving Karsbøl; Kenneth Lasseter;
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作者单位

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年(卷),期 -1(56),11
年度 -1
页码 1381–1390
总页数 10
原文格式 PDF
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中图分类外科学;
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1. Pharmacokinetics and Tolerability of a Single Dose of Semaglutide, a Human Glucagon-Like Peptide-1 Analog, in Subjects With and Without Renal Impairment [J] . Thomas C. Marbury, Anne Flint, Jacob B. Jacobsen, Clinical pharmacokinetics . 2017,第11期

机译：药代动力学和单剂量半蛋白质的耐受性，一种人胰高血糖素样肽-1类似物，在有肾损伤的受试者中
2. Effect of Various Dosing Conditions on the Pharmacokinetics of Oral Semaglutide, a Human Glucagon-Like Peptide-1 Analogue in a Tablet Formulation [J] . B?kdal Tine A., Breitschaft Astrid, Donsmark Morten, Diabetes therapy . 2021,第7期

机译：各种计量条件对口服半蛋白质药代动力学的影响，一种平板制剂中的人胰高血糖素样肽-1类似物
3. Pharmacokinetics and tolerability of a novel long-acting glucagon-like peptide-1 analog, CJC-1131, in healthy and diabetic subjects. [J] . Tiessen RG, Castaigne JP, Dreyfus JF, International journal of clinical pharmacology and therapeutics . 2008,第9期

机译：新型长效胰高血糖素样肽1类似物CJC-1131在健康和糖尿病患者中的药代动力学和耐受性。
4. Novel Application of SCIEX 6600 TripleTOF Mass Spectrometer for Quantitative Assessment of Glucagon-Like Peptide-1 (GLP-1) Analog Pharmacokinetic Studies [C] . Yue Huang, Sarah Will, Anish Konkar, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：SCIEX 6600三重型质谱仪用于定量评估胰高血糖素肽-1（GLP-1）模拟药代动力学研究的新型施用
5. Glucagon-like peptide-1 (GLP-1) and liraglutide, a synthetic GLP-1 analog, inhibit inflammation in human aortic endothelial cells via calcium and AMPK dependent mechanisms [D] . Krasner, Nadia Marie 2014

机译：胰高血糖素样肽-1（GLP-1）和Liraglutide，一种合成GLP-1模拟，通过钙和AMPK依赖机制抑制人主动脉内皮细胞中的炎症
6. Effect of Various Dosing Conditions on the Pharmacokinetics of Oral Semaglutide a Human Glucagon-Like Peptide-1 Analogue in a Tablet Formulation [O] . Tine A. Bækdal, Astrid Breitschaft, Morten Donsmark, 2021

机译：各种计量条件对口服半蛋白质药代动力学的影响一种片剂配方中的人胰高血糖素样肽-1类似物
7. Pharmacokinetics and Tolerability of a Single Dose of Semaglutide, a Human Glucagon-Like Peptide-1 Analog, in Subjects With and Without Renal Impairment [O] . Thomas C. Marbury, Anne Flint, Jacob B. Jacobsen, 2017

机译：单剂量西马鲁肽（一种人胰高血糖素样肽-1类似物）在有或没有肾功能障碍的受试者中的药代动力学和耐受性

Pharmacokinetics and Tolerability of a Single Dose of Semaglutide a Human Glucagon-Like Peptide-1 Analog in Subjects With and Without Renal Impairment

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