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Anti-Invasive and Anti-Proliferative Effects of shRNA-Loaded Poly(Lactide-Co-Glycolide) Nanoparticles Following RAN Silencing in MDA-MB231 Breast Cancer Cells

机译：在RAN沉默MDA-MB231乳腺癌细胞后shRNA负载的聚（丙交酯-乙交酯）纳米颗粒的抗侵袭和抗增殖作用。

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BackgroundOverexpression of the RAN GTP (RAN) gene has been shown to be linked to metastatic activity of MDA-MB231 human breast cancer cells by increasing Ras/MEK/ERK and PI3K/Akt/mTORC1 signalling. The aim of this study was to investigate the potential of polymeric nanoparticles to deliver two novel shRNA sequences, targeted against the RAN gene, to MDA-MB231 cells grown in culture and to assess their effects in a range of biological assays.

机译：背景已显示，RAN GTP（RAN）基因的过表达通过增加Ras / MEK / ERK和PI3K / Akt / mTORC1信号传导与MDA-MB231人乳腺癌细胞的转移活性相关。这项研究的目的是研究聚合物纳米颗粒向培养的MDA-MB231细胞提供两种针对RAN基因的新型shRNA序列的潜力，并评估其在一系列生物学检测中的作用。

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期刊名称 Springer Open Choice
作者
Ankur Sharma; Paul McCarron; Kyle Matchett; Susan Hawthorne; Mohamed El-Tanani;
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作者单位

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年(卷),期 -1(36),2
年度 -1
页码 26
总页数 13
原文格式 PDF
正文语种
中图分类外科学;
关键词
Breast cancer Intracellular delivery Nanotechnology PLGA shRNA;

机译：乳腺癌;细胞内递送;纳米技术;PLGA;shRNA;

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专利

1. Anti-Invasive and Anti-Proliferative Effects of shRNA-Loaded Poly(Lactide-Co-Glycolide) Nanoparticles Following RAN Silencing in MDA-MB231 Breast Cancer Cells [J] . Sharma Ankur, McCarron Paul, Matchett Kyle, Pharmaceutical research . 2019,第2期

机译：在MDA-MB231乳腺癌细胞中RAN沉默后的抗侵袭性和抗增殖效果纳米颗粒在MDA-MB231乳腺癌细胞中
2. Targeting endothelin A receptor enhances anti-proliferative and anti-invasive effects of the HER2 antibody trastuzumab in HER2-overexpressing breast cancer cells. [J] . Fischgrabe J, Gotte M, Michels K, International Journal of Cancer =: Journal International du Cancer . 2010,第3期

机译：靶向内皮素A受体可增强HER2过表达的乳腺癌细胞中HER2抗体曲妥珠单抗的抗增殖和抗侵袭作用。
3. PREPARATION AND CHARACTERIZATION OF TUMOR CELL LYSATE AND POLY-IC LOADED POLY ( LACTIC-CO-GLYCOLIC ACID) NANOPARTICLES AND EVALUATION OF THEIR ANTI-TUMOR EFFECTS IN MOUSE MODEL OF BREAST CANCER [J] . sanaz Sheikhzadeh, Nowruz Delirezh, Rahim Hobbenaghi Majallah-i pizishki-i Urumiyah. . 2018,第8期

机译：乳腺癌细胞模型中肿瘤细胞裂解物和多聚乳酸（乳酸-乙醇酸）纳米粒的制备，表征及抗肿瘤作用的评价
4. Novel Glyco-lipid-arsenicals (III) with Anti-proliferative Effects on MCF-7 Human Breast Cancer Cells [C] . Norbert Wimmer, Jodie A. Robinson, Nagaraj Gopisetty-Venkatta American Peptide Symposium . 2006

机译：新型甘油 - 脂质 - 砷（III）对MCF-7人乳腺癌细胞的抗增殖作用
5. A Novel Phytoalexin, Glyceollins, Triggers Anti-Proliferative and Apoptotic Effects in Letrozole Resistant T47d Breast Cancer Cells [D] . Walker, Rashidra R. 2020

机译：一种新的植物碱，Glyceollins，触发抗增殖和凋亡作用在Letrozole抗性T47D乳腺癌细胞中
6. Evaluating Inhibitory Effects of Paclitaxel and Vitamin D3 Loaded Poly Lactic Glycolic Acid Co-Delivery Nanoparticles on the Breast Cancer Cell Line [O] . Sepideh Khodaverdi, Alireza Jafari, Farahnaz Movahedzadeh, 2020

机译：评价紫杉醇和维生素D3载聚乳酸乙醇酸共传递纳米粒子对乳腺癌细胞株的抑制作用。
7. Anti-Invasive and Anti-Proliferative Effects of shRNA-Loaded Poly(Lactide-Co-Glycolide) Nanoparticles Following RAN Silencing in MDA-MB231 Breast Cancer Cells [O] . Ankur Sharma, Paul McCarron, Kyle Matchett, 2018

机译：在MDA-MB231乳腺癌细胞中RAN沉默后的ShRNA负载聚（丙交酯 - 共乙酰基）纳米颗粒的抗侵袭性和抗增殖效果
8. Dynamics of Intracellular Uptake of Surface Modified Poly (d, L- Lactide-co-Glycolide) Nanoparticles in Breast Cancer Cells (Rev). [R] . Masinde, L. 2004

机译：表面修饰的聚（d，L-丙交酯 - 共 - 乙交酯）纳米颗粒在乳腺癌细胞中的细胞内摄取动力学（Rev）。

Anti-Invasive and Anti-Proliferative Effects of shRNA-Loaded Poly(Lactide-Co-Glycolide) Nanoparticles Following RAN Silencing in MDA-MB231 Breast Cancer Cells

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