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PPAR-γ Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic β-Cells

机译：PPAR-γ激活通过胰腺β细胞中游离脂肪酸受体GPR40的上调增加胰岛素分泌。

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BackgroundIt has been reported that peroxisome proliferator-activated receptor (PPAR)-γ and their synthetic ligands have direct effects on pancreatic β-cells. We investigated whether PPAR-γ activation stimulates insulin secretion through the up-regulation of GPR40 in pancreatic β-cells.

机译：背景技术已经报道过氧化物酶体增殖物激活受体（PPAR）-γ及其合成配体对胰腺β细胞具有直接作用。我们研究了PPAR-γ激活是否通过上调胰腺β细胞中GPR40的表达来刺激胰岛素分泌。

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期刊名称 PLoS Clinical Trials
作者
Hyo-Sup Kim; You-Cheol Hwang; Seung-Hoi Koo; Kyong Soo Park; Myung-Shik Lee; Kwang-Won Kim; Moon-Kyu Lee;
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年(卷),期 2010(8),1
年度 2010
页码 e50128
总页数 12
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专利

1. Activation of Extracellular Signal-Regulated Protein Kinases 1 and 2 (ERK1/2) by Free Fatty Acid Receptor 1 (FFAR1/GPR40) Protects from Palmitate-Induced Beta Cell Death, but Plays no Role in Insulin Secretion [J] . Madhura Panse, Felicia Gerst, Gabriele Kaiser, Cellular Physiology and Biochemistry . 2015,第4期

机译：游离脂肪酸受体1（FFAR1 / GPR40）激活的细胞外信号调节蛋白激酶1和2（ERK1 / 2）的保护免受棕榈酸酯诱导的β细胞死亡，但在胰岛素分泌中不起作用
2. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40 [J] . Itoh Y., Kawamata Y., Harada M., Nature . 2003,第6928期

机译：游离脂肪酸通过GPR40调节胰腺β细胞的胰岛素分泌
3. Long-term in vitro treatment of INS-1 rat pancreatic β-cells by unsaturated free fatty acids protects cells against gluco- and lipotoxicities via activation of GPR40 receptors [J] . TuoY., FengD.D., WangD.-F., Clinical and experimental pharmacology & physiology . 2012,第5期

机译：不饱和游离脂肪酸对INS-1大鼠胰腺β细胞的长期体外治疗可通过激活GPR40受体来保护细胞免受葡萄糖和脂毒性
4. EVALUATION OF INSULIN SECRETION BY PANCREATIC CELLS IN RESPONSE TO INCREASING AMOUNTS OF GLUCOSE [C] . Lamar Hamil, Ham Benghuzzi, Michelle Tucci Annual Rocky Mountain Bioengineering Symposium . 2008

机译：胰腺细胞响应葡萄糖量增加的胰岛素分泌评价
5. The Short Chain Fatty Acid Receptor, Free Fatty Acid-2 Receptor (FFA2), Contributes to Gestational Glucose Homeostasis through a Novel Relationship Between Pancreatic Beta Cells, Short Chain Fatty Acids and the Gut Microbiota. [D] . Fuller, Miles Henry. 2016

机译：短链脂肪酸受体，游离脂肪酸2受体（FFA2）通过胰腺β细胞，短链脂肪酸和肠道菌群之间的新关系，有助于妊娠期葡萄糖体内稳态。
6. Increased Glucose Metabolism and Glycerolipid Formation by Fatty Acids and GPR40 Receptor Signaling Underlies the Fatty Acid Potentiation of Insulin Secretion [O] . Mahmoud El-Azzouny, Charles R. Evans, Mary K. Treutelaar, 2014

机译：脂肪酸和GPR40受体信号增强的葡萄糖代谢和甘油脂形成是胰岛素分泌的脂肪酸增强的基础。
7. PPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cells. [O] . Hyo-Sup Kim, You-Cheol Hwang, Seung-Hoi Koo, 2013

机译：ppaR-γ活化通过胰腺β-细胞中游离脂肪酸受体GpR40的上调来增加胰岛素分泌。

PPAR-γ Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic β-Cells

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