Loss of yata a Novel Gene Regulating the Subcellular Localization of APPL Induces Deterioration of Neural Tissues and Lifespan Shortening

摘要

BackgroundThe subcellular localization of membrane and secreted proteins is finely and dynamically regulated through intracellular vesicular trafficking for permitting various biological processes. Drosophila Amyloid precursor protein like (APPL) and Hikaru genki (HIG) are examples of proteins that show differential subcellular localization among several developmental stages.