1983. Oral Therapy with Rifampin Associated with Minocycline or Moxifloxacin in Vertebral Osteomyelitis due to Gram-Positive Micro-organisms: A Retrospective Study of 64 Cases

摘要

BackgroundIDSA guidelines about vertebral osteomyelitis (VO) recommend parenteral antimicrobial therapy (PAT) as the standard treatment for Gram-positive pathogens (GPP). In this setting, a switch to oral antimicrobial therapy (OAT) with excellent bioavailability could be considered. However, among fluoroquinolones, moxifloxacine is not recommended in staphylococcal VO, and among tetracycline, only doxycycline should be considered with rifampin, for brucelar VO. The aim of our study was to review the efficacy and safety of OAT with rifampin associated with moxifloxacin (Rif-Mox) or minocycline (Rif-Mino) in the treatment of VO due to GPP.