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Therapeutic Mucosal Vaccination of Herpes Simplex Virus 2-Infected Guinea Pigs with Ribonucleotide Reductase 2 (RR2) Protein Boosts Antiviral Neutralizing Antibodies and Local Tissue-Resident CD4+ and CD8+ TRM Cells Associated with Protection against Recurrent Genital Herpes

机译：用核糖核苷酸还原酶2（RR2）蛋白对单纯疱疹病毒2感染的豚鼠进行治疗性粘膜疫苗接种可增强抗病毒中和抗体以及与预防复发性生殖器疱疹相关的局部组织驻留性CD4 +和CD8 + TRM细胞。

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期刊名称 Journal of Virology
作者
Ruchi Srivastava; Soumyabrata Roy; Pierre-Gregoire Coulon; Hawa Vahed; Swayam Prakash; Nisha Dhanushkodi; Grace J. Kim; Mona A. Fouladi; Joe Campo; Andy A. Teng; Xiaowu Liang; Hubert Schaefer; Lbachir BenMohamed;
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年(卷),期 2019(93),9
年度 2019
页码 e02309-18
总页数 24
原文格式 PDF
正文语种
中图分类人体病毒学（致病病毒）;病毒（滤过性病毒）;
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专利

1. Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs [J] . Lauren M. Hook, Tina M. Cairns, Sita Awasthi, PLoS Pathogens . 2018,第5期

机译：涉及病毒进入和细胞间传播的单纯疱疹病毒糖蛋白D表位的疫苗诱导抗体与豚鼠生殖器疾病的保护相关
2. Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs [J] . Lauren M. Hook, Tina M. Cairns, Sita Awasthi, PLoS Pathogens . 2018,第5期

机译：涉及病毒进入和细胞间传播的单纯疱疹病毒糖蛋白D表位的疫苗诱导抗体与豚鼠生殖器疾病的保护相关
3. Suppression of recurrent genital herpes simplex virus type 2 infection by Rhus javanica in guinea pigs (published erratum appears in Antiviral Res 1999 Apr;41(3):153-4) [J] . Nakano M, Kurokawa M, Hozumi T, Antiviral Research . 1998,第1期

机译：Rhus javanica抑制豚鼠对生殖器单纯性疱疹病毒2型的反复感染（发表的勘误表载于Antiviral Res 1999 Apr; 41（3）：153-4）
4. Blockade of PD-1 and LAG-3 Immune Checkpoints Combined with Vaccination Restores the Function of Antiviral Tissue-Resident CD8+ TRM Cells and Reduces Ocular Herpes Simplex Infection and Disease in HLA Transgenic Rabbits [O] . Soumyabrata Roy, Pierre-Gregoire Coulon, Swayam Prakash, 2019

机译：阻断PD-1和LAG-3免疫检查点并结合疫苗接种可恢复抗病毒组织常驻CD8 + TRM细胞的功能并减少HLA转基因兔的眼单纯疱疹感染和疾病
5. Therapeutic Mucosal Vaccination of Herpes Simplex Virus 2-Infected Guinea Pigs with Ribonucleotide Reductase 2 (RR2) Protein Boosts Antiviral Neutralizing Antibodies and Local Tissue-Resident CD4 + and CD8 + T RM Cells Associated with Protection against Recurrent Genital Herpes [O] . Ruchi Srivastava, Soumyabrata Roy, Pierre-Gregoire Coulon, 2019

机译：疱疹病毒的治疗粘膜疫苗疫苗接种核糖核苷酸还原酶2（RR2）蛋白的豚鼠促进抗病毒中和抗体和局部组织 - 驻留CD4 +和CD8 + T RM细胞，与反复性生殖器疱疹的保护相关

Therapeutic Mucosal Vaccination of Herpes Simplex Virus 2-Infected Guinea Pigs with Ribonucleotide Reductase 2 (RR2) Protein Boosts Antiviral Neutralizing Antibodies and Local Tissue-Resident CD4+ and CD8+ TRM Cells Associated with Protection against Recurrent Genital Herpes

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