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Changes in tissue oxyhaemoglobin concentration measured usingmultichannel near infrared spectroscopy during internal carotidangiography

机译:使用以下方法测量的组织氧合血红蛋白浓度的变化颈内动脉多通道近红外光谱血管造影

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摘要

OBJECTIVE—To develop an in vivo model for testing spatially resolved spectroscopy and quantified near infrared spectroscopy (NIRS) cerebral blood flow measurements.
METHOD—Multiple detector NIRS has been used to study changes in tissue oxyhaemoglobin (O2Hb) concentration during selective internal carotid angiography. A significant reduction in O2Hb occurred in tissue interrogated by detectors situated between 0.7 and 4.1cm from the NIRS light source.
RESULTS—The time course of O2Hb concentration change was consistent with displacement of oxygenated blood by the radiocontrast medium from vascular beds of differing flow and NIR light attenuation. Increasing changes in O2Hb concentration per unit photon path length—predicted to occur at greater emitter-detector separations if those changes had occurred predominantly in cerebral tissue—were found in the first four seconds after injection of radiocontrast medium. However, later changes (6-10 s) were larger and were not proportional to emitter-detector separation.
CONCLUSION—The findings indicate that simple assumptions regarding the distribution of the internal carotid artery blood supply to cerebral and extracerebral tissues, the photon pathlength through those tissues, and their relative contributions toattenuation of NIR light may not be justified.

机译:目的—建立体内模型以测试空间分辨光谱法和定量近红外光谱法(NIRS)脑血流量。
方法—多重检测器NIRS已用于研究选择性期间组织氧合血红蛋白(O2Hb)浓度的变化颈内动脉造影。在距NIRS光源0.7到4.1厘米之间的探测器询问的组织中,O2Hb的含量显着降低。
结果—O2Hb浓度变化的时间过程与放射性造影剂从血管床置换含氧血液相一致不同的流量和近红外光衰减。在注入放射性对比剂后的最初四秒钟内,发现每单位光子路径长度的O2Hb浓度变化增加(如果这些变化主要发生在脑组织中,则预计会在更大的发射器-检测器间距处发生)。但是,后来的变化(6-10 s)更大,并且与发射器-探测器的分离不成比例。
结论—研究结果表明,关于颈内动脉向大脑和脑外组织供血分布的简单假设,光子路径这些组织的长度,以及它们对NIR光的衰减可能不合理。

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