机译
针对代谢异常的脂肪褐变:临床观点
摘要:A severe burn injury is one of the most devastating injuries and is associated with a high risk of mortality (~180,000 deaths per year worldwide) [ ]. In addition to large wounds, severe burns can result in injury-induced hypermetabolism, which is a major challenge faced by clinicians in the treatment of patients [ ]. Hypermetabolism is known to trigger a plethora of metabolic disorders including type 2 diabetic milieu, fatty liver, sepsis and multiple organ failure [ , ]. As a matter of fact, hypermetabolism can persist for years, consistently putting a high demand of energy on the body, thus making it extremely difficult for the metabolic system to meet the body’s existing nutritional requirements [ ]. The hypermetabolic response in burn patients can be triggered by a wide variety of signaling mediators such as catecholamines, glucocorticoids, cytokines or other inflammatory signaling mediators, making it very heterogeneous in nature [ ]. Given the challenges induced by hypermetabolism in burn patients, there is a growing need to understand and modulate hypermetabolism in burn patients to improve their clinical outcomes.