机译
Cancabis for Covid-19:Cannaminoids可以平息细胞因子风暴吗?
摘要:The recent emergence of SARS coronavirus 2 (SARS-CoV-2) has resulted in the alarming spread of the highly infectious and contagious COVID-19 pandemic that is causing catastrophic damage and affecting health, life and death around the world [1,2]. SARS-CoV-2 has also created a COVID-19 ‘infodemic’ crisis with an overabundance of information and misinformation about the origin of the virus, potential therapies, and whether it was engineered in the laboratory. However, the global pace of SARS-CoV-2 and COVID-19 research is providing rapid and critical advances in comparison to that of the previous SARS-CoV, Middle East respiratory syndrome (MERS) and HIV [1,3,4]. COVID-19 has a protean manifestation, and the cryptic transmission of SARS-CoV-2 is characterized by multiple chains of transmission, unlike the SARS-CoV and MERS-CoV viruses that have been reported to occur mainly through nosocomial transmission [3,4]. There are still many unknowns regarding COVID-19, but there are also important lessons to be gleaned from AIDS that are applicable to the COVID-19 pandemic. They are both zoonotic diseases with different mode of transmission, with no vaccine or cure yet; however, there is an effective antiretroviral therapy for AIDS [5,6]. Furthermore, cannabis and cannabinoids have been proposed and used as adjunctive treatment for AIDS-associated cachexia, and in reduction of disease symptoms [7,8]. The processes of inflammation are important in both the pathogenesis of AIDS and COVID-19 [6,8]. Cannabinoids are effective at suppressing immune and inflammatory functions [7–9], and their potential as an anti-inflammatory treatment in COVID-19 has been suggested [8,9].