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Circulating tumor cells and γH2AX as biomarkers for responsiveness to radium-223 in advanced prostate cancer patients

机译：循环肿瘤细胞和γH2AX作为晚期前列腺癌患者对镭223应答的生物标志物

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摘要

Radium-223 improves overall survival in patients with metastatic castration-resistant prostate cancer to the bone. Radium-223 causes double-strand DNA breaks and produces γH2AX, a potential biomarker for response. We examined the feasibility of tracking γH2AX positivity and numeration in circulating tumor cells.

机译：Radium-223改善了转移性去势抵抗性前列腺癌患者的总体生存率。 Radium-223引起双链DNA断裂并产生γH2AX，这是一种潜在的反应生物标记。我们研究了在循环肿瘤细胞中追踪γH2AX阳性和计数的可行性。

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期刊名称 Future Science OA
作者
Jonathan Chatzkel; Jesse Mocha; Johnna Smith; Jun-Min Zhou; Youngchul Kim; Ghassan El-Haddad; Jingsong Zhang;
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作者单位

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年(卷),期 2020(6),1
年度 2020
页码 -1
总页数 10
原文格式 PDF
正文语种
中图分类情报学;
关键词
biomarkers; circulating tumor cells; homologous repair deficiency; metastatic castrate-resistant prostate cancer; radium-223; γH2AX;

机译：生物标志物;循环肿瘤细胞;同源修复缺陷;转移去势抵抗性前列腺癌;radium-223;γH2AX;

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专利

1. Circulating tumor cells and γH2AX as biomarkers for responsiveness to radium-223 in advanced prostate cancer patients [J] . Jonathan Chatzkel, Jesse Mocha, Johnna Smith, Future Science OA . 2020,第1期

机译：循环肿瘤细胞和γH2AX作为生物标志物，用于对晚期前列腺癌患者的镭至223反应
2. Letter to the Editor: “Circulating Cell-Free DNA and Circulating Tumor Cells as Prognostic and Predictive Biomarkers in Advanced Non-Small Cell Lung Cancer Patients Treated with First-Line Chemotherapy” [J] . Chiara Nicolazzo, Cristina Raimondi, Flavia Loreni, International Journal of Molecular Sciences . 2017,第6期

机译：致编辑的信：“循环无细胞DNA和循环肿瘤细胞是一线化疗治疗的晚期非小细胞肺癌患者的预后和预测生物标志物”
3. Circulating Cell-Free DNA and Circulating Tumor Cells as Prognostic and Predictive Biomarkers in Advanced Non-Small Cell Lung Cancer Patients Treated with First-Line Chemotherapy [J] . Simona Coco, Angela Alama, Irene Vanni, International Journal of Molecular Sciences . 2017,第5期

机译：一线化疗治疗晚期非小细胞肺癌患者的循环无细胞DNA和循环肿瘤细胞作为预后和预测生物标志物。
4. Using a Bioreactor System to Identify Biomarkers for Breast Cancer Circulating Tumor Cells [C] . Kenneth Fuh, Robert Shepherd, Sunyoung Park, International Molecular Medicine Tri-Conference. . 2015

机译：使用生物反应器系统鉴定乳腺癌循环肿瘤细胞的生物标志物
5. Comparative Analysis on Innate Immune System Function in Metastatic Breast, Colorectal, and Prostate Cancer Patients with Circulating Tumor Cells [D] . Santos, Mark Anthony Francisco. 2014

机译：转移性乳腺癌，结直肠癌和前列腺癌患者循环肿瘤细胞先天免疫系统功能的比较分析
6. Reply to the Letter to the Editor by C. Nicolazzo et al.: Circulating Cell-Free DNA and Circulating Tumor Cells as Prognostic and Predictive Biomarkers in Advanced Non-Small Cell Lung Cancer Patients Treated with First-Line Chemotherapy [O] . Angela Alama, Simona Coco, Irene Vanni, 2017

机译：回复C. Nicolazzo等人给编辑的信：循环无细胞DNA和循环肿瘤细胞作为一线化疗治疗的晚期非小细胞肺癌患者的预后和预测生物标志物
7. Letter to the Editor: “Circulating Cell-Free DNA and Circulating Tumor Cells as Prognostic and Predictive Biomarkers in Advanced Non-Small Cell Lung Cancer Patients Treated with First-Line Chemotherapy” [O] . Nicolazzo, Chiara, Raimondi, Cristina, Loreni, Flavia, 2017

机译：致编辑的信：“循环无细胞DNA和循环肿瘤细胞作为一线化疗治疗的晚期非小细胞肺癌患者的预后和预测生物标志物”

Circulating tumor cells and γH2AX as biomarkers for responsiveness to radium-223 in advanced prostate cancer patients

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