ATP-loaded biomimetic nanoparticles as controlled release system for extracellular drugs in cancer applications

摘要

PurposeThe antitumoral effect of ATP requires its accumulation in the extracellular space to interact with membrane receptors in target cells. We propose the use of albumin nanoparticles (ANPs) coated with erythrocyte membranes (EMs) to load, deliver, release, and enhance the extracellular anticancer activity of ATP.