Enhanced oral bioavailability of a sterol-loaded microemulsion formulation of Flammulina velutipes a potential antitumor drug

机译：金针菇（一种潜在的抗肿瘤药物）的固醇微乳制剂的口服生物利用度提高

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PurposeTo investigate the growth inhibition activity of Flammulina velutipes sterol (FVS) against certain human cancer cell lines (gastric SGC and colon LoVo) and to evaluate the optimum microemulsion prescription, as well as the pharmacokinetics of encapsulated FVS.

机译：目的研究金针菇固醇（FVS）对某些人类癌细胞系（胃SGC和结肠LoVo）的生长抑制活性，并评估最佳微乳处方以及包封的FVS的药代动力学。

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期刊名称 International Journal of Nanomedicine
作者
Chengxue Yi; Hui Zhong; Shanshan Tong; Xia Cao; Caleb K Firempong; Hongfei Liu; Min Fu; Yan Yang; Yingshu Feng; Huiyun Zhang; Ximing Xu; Jiangnan Yu;
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作者单位

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年(卷),期 2012(7),-1
年度 2012
页码 5067–5078
总页数 12
原文格式 PDF
正文语种
中图分类生化遗传学;生化药理学;
关键词
Flammulina velutipes sterol microemulsions pharmacokinetics bioavailability;

机译：金针菇固醇;微乳;药代动力学;生物利用度;

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专利

1. Enhanced oral bioavailability of a sterol-loaded microemulsion formulation of Flammulina velutipes, a potential antitumor drug [J] . Chengxue Yi, Hui Zhong, Shanshan Tong, International Journal of Nanomedicine . 2012,第2期

机译：金针菇（一种潜在的抗肿瘤药物）的固醇微乳制剂的口服生物利用度提高
2. Enhanced Oral Bioavailability and Tissue Distribution of a New Potential Anticancer Agent, Flammulina velutipes Sterols, through Liposomal Encapsulation [J] . Chengxue Yi, Min Fu, Xia Cao Journal of Agricultural and Food Chemistry . 2013,第25期

机译：通过脂质体包囊增强了新型潜在抗癌剂金针菇甾醇的口服生物利用度和组织分布。
3. Optimized mixed oils remarkably reduce the amount of surfactants in microemulsions without affecting oral bioavailability of ibuprofen by simultaneously enlarging microemulsion areas and enhancing drug solubility [J] . Chen Yizhen, Tuo Jue, Huang Huizhi, International Journal of Pharmaceutics . 2015,第1a2期

机译：优化的混合油可通过同时扩大微乳剂面积并增强药物溶解度，显着减少微乳剂中表面活性剂的量，而不会影响布洛芬的口服生物利用度
4. Enhanced oral bioavailability of poorly water soluble drugs by a novel solid SMEDDS formulation [C] . Prabaqar Balakrishnan, Dong Hoon Oh, Chul Soon Yong, Annual meeting exposition of the Controlled Release Society . 2011

机译：通过新型固体SMEDDS制剂提高水溶性差的药物的口服生物利用度
5. EFFECT OF FORMULATIONS, SURFACTANTS, AND SOLVENTS UPON THE ORAL BIOAVAILABILITY OF POORLY SOLUBLE DRUGS IN THE BLOOD AND LYMPH. [D] . GOWAN, WALTER GARRETT, JR. 1985

机译：配方，表面活性剂和溶剂对血液和淋巴液中难溶性药物口服生物利用度的影响。
6. Modulating Drug Release and Enhancing the Oral Bioavailability of Torcetrapib with Solid Lipid Dispersion Formulations [O] . Yajun Liu, Gino M. Salituro, Keun-joong Lee, 2015

机译：固体脂质分散体制剂调节药物释放并提高Torcetrapib的口服生物利用度
7. Peg-5 Oleate Based Self Microemulsifying Drug Delivery System: As a Versatile Approach in Oral Bioavailability Enhancement of Anti-Diabetic Agent: Formulation Design, vitro/In vivo Evaluation Stability Studies [O] . Seema Kohli 2018

机译：PEG-5基于油酸的自我微乳化药物递送系统：作为口服生物利用度的多功能方法，增强抗糖尿病药剂：配方设计，体外/体内评价和稳定性研究

Enhanced oral bioavailability of a sterol-loaded microemulsion formulation of Flammulina velutipes a potential antitumor drug

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