Paclitaxel-Fe3O4 nanoparticles inhibit growth of CD138− CD34− tumor stem-like cells in multiple myeloma-bearing mice

机译：紫杉醇-Fe3O4纳米颗粒抑制多发性骨髓瘤小鼠中CD138- CD34-肿瘤干细胞的生长

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摘要

BackgroundThere is growing evidence that CD138⁻ CD34⁻ cells may actually be tumor stem cells responsible for initiation and relapse of multiple myeloma. However, effective drugs targeted at CD138⁻ CD34⁻ tumor stem cells are yet to be developed. The purpose of this study was to investigate the inhibitory effect of paclitaxel-loaded Fe3O4 nanoparticles (PTX-NPs) on CD138⁻ CD34⁻ tumor stem cells in multiple myeloma-bearing mice.

机译：背景技术越来越多的证据表明CD138 ^{- CD34 ^{-细胞实际上可能是导致多发性骨髓瘤发生和复发的肿瘤干细胞。然而，针对CD138 ^{- CD34 ^{-肿瘤干细胞的有效药物尚待开发。这项研究的目的是研究紫杉醇负载的Fe3O4纳米颗粒（PTX-NPs）对多发性骨髓瘤小鼠CD138 ^{- CD34 ^{-肿瘤干细胞的抑制作用。}}}}}}

著录项

期刊名称 International Journal of Nanomedicine
作者
Cuiping Yang; Jing Wang; Dengyu Chen; Junsong Chen; Fei Xiong; Hongyi Zhang; Yunxia Zhang; Ning Gu; Jun Dou;
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作者单位

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年(卷),期 2013(8),-1
年度 2013
页码 1439–1449
总页数 11
原文格式 PDF
正文语种
中图分类生化遗传学;生化药理学;
关键词
multiple myeloma tumor stem cells Fe3O4 nanoparticles paclitaxel;

机译：多发性骨髓瘤;肿瘤干细胞;Fe3O4纳米颗粒;紫杉醇;

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专利

1. Paclitaxel-Fe3O4 nanoparticles inhibit growth of CD138–? CD34– tumor stem-like cells in multiple myeloma-bearing mice [J] . Cuiping Yang, ?Jing Wang, Dengyu Chen, International Journal of Nanomedicine . 2013,第1期

机译：紫杉醇-Fe3O4纳米颗粒抑制CD138–？患有多发性骨髓瘤的小鼠中的CD34–肿瘤干样细胞
2. Paclitaxel-Fe3O4 nanoparticles inhibit growth of CD138–? CD34– tumor stem-like cells in multiple myeloma-bearing mice [J] . Cuiping Yang, ?Jing Wang, Dengyu Chen, International Journal of Nanomedicine . 2013,第1期

机译：紫杉醇-Fe3O4纳米颗粒抑制CD138–？患有多发性骨髓瘤的小鼠中的CD34–肿瘤干样细胞
3. Super-charged NK cells inhibit growth and progression of stem-like/poorly differentiated oral tumors in vivo in humanized BLT mice; effect on tumor differentiation and response to chemotherapeutic drugs [J] . Kawaljit Kaur, Paytsar Topchyan, Anna Karolina Kozlowska, Oncoimmunology. . 2018,第5期

机译：超电荷的NK细胞抑制人源化的BLT小鼠体内干燥的茎状/差异化口腔肿瘤的生长和进展; 对化学治疗药物的肿瘤分化和反应的影响
4. Total Paeony Glycoside Inhibits Tumor Growth and Induces Apoptosis in K562 Cells and in S180 Tumor-Bearing Mice [C] . Huiyu Xu, Yanmin Wu, Xiaoqing Luo, Information technology and agricultural engineering . 2011

机译：总Pa药苷抑制K562细胞和S180荷瘤小鼠的肿瘤生长并诱导其凋亡。
5. Super-charged NK cells increase immune infiltration in the tumor microenvironment and inhibit tumor growth in humanized-BLT mice. [D] . Kaur, Kawaljit. 2017

机译：荷电的NK细胞增加了肿瘤微环境中的免疫浸润，并抑制了人源化BLT小鼠的肿瘤生长。
6. Super-charged NK cells inhibit growth and progression of stem-like/poorly differentiated oral tumors in vivo in humanized BLT mice; effect on tumor differentiation and response to chemotherapeutic drugs [O] . Kawaljit Kaur, Paytsar Topchyan, Anna Karolina Kozlowska, 2018

机译：荷电的NK细胞在人源化BLT小鼠体内抑制干样/低分化口腔肿瘤的生长和进程；对肿瘤分化和对化疗药物反应的影响
7. Novel Retinoic Acid Metabolism Blocking Agents Endowed with Multiple Biological Activities Are Efficient Growth Inhibitors of Human Breast and Prostate Cancer Cells in Vitro and a Human Breast Tumor Xenograft in Nude Mice [O] . -1

机译：具有多种生物活性的新型视黄酸代谢阻断剂是人乳腺癌和前列腺癌细胞的有效生长抑制剂在体外和裸鼠中的人乳腺肿瘤异种移植物

Paclitaxel-Fe3O4 nanoparticles inhibit growth of CD138− CD34− tumor stem-like cells in multiple myeloma-bearing mice

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