Conversion of apoptosis to necrosis and the corresponding alteration in the oxidative milieu of male germ cells of rat under acute heat stress: An experimental study

摘要

Background:Increased scrotal temperature can disrupt spermatogenesis leading to male infertility. Germ cells being heat sensitive maintain their genetic integrity via protective mechanism originated from the cell itself or by means of cell death. However, qualitative differentiation of how reactive oxygen species and antioxidant enzymes regulate signaling pathways of cellular damage including DNA fragmentation at varied temperatures remains unexplored.