An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell

摘要

Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signaling in pancreatic β-cells.^– These studies have highlighted a role for NAADP-induced Ca²⁺ mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.