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Repeated injections of orexin-A developed behavioral tolerance to its analgesic effects in rats

机译：重复注射orexin-A对大鼠的镇痛作用产生了行为耐受性

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摘要

Objective(s):Reduction of pharmacological effectiveness or tolerance appears following repeated administration of many analgesic drugs. We investigated tolerance to anti-nociceptive effects of orexin-A, an endogenous potent analgesic peptide using the hot-plate test.

机译：目标：重复服用多种镇痛药后，药理效力或耐受性下降。我们使用热板试验研究了对内源性强效镇痛肽orexin-A的抗伤害感受作用的耐受性。

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期刊名称 Iranian Journal of Basic Medical Sciences
作者
Elmira Ghasemi; Nima Heidari-Oranjaghi; Hassan Azhdari-Zarmehri; Mehdi Sadegh;
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作者单位

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年(卷),期 2015(18),12
年度 2015
页码 1183–1188
总页数 8
原文格式 PDF
正文语种
中图分类
关键词
Anti-nociception Hot plate Orexin-A Tolerance;

机译：抗伤害感受;热板;Orexin-A;耐受性;

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2. Behavioral sensitization, behavioral tolerance, and increased (3H)WIN 35,428 binding in rabbit caudate nucleus after repeated injections of cocaine. [J] . Aloyo VJ, Pazdalski PS, Kirifides AL, Pharmacology, Biochemistry and Behavior . 1995 ,第2期

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3. The rate of behavioral tolerance development to repeated lipopolysaccharide treatments depends upon the time of injection during the light-dark cycle: a multivariable examination of locomotor activity. [J] . Franklin AE, Engeland CG, Kavaliers M, Behavioural Brain Research: An International Journal . 2007 ,第2期

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Repeated injections of orexin-A developed behavioral tolerance to its analgesic effects in rats

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