G protein-coupled receptors (GPCRs) constitute the key component of cellular signal transduction. Accurately annotating the biological functions of GPCR proteins is vital to the understanding of the physiological processes they involve in. With the rapid development of text mining technologies and the exponential growth of biomedical literature, it becomes urgent to explore biological functional information from various literature for systematically and reliably annotating these known GPCRs. We design a novel three-stage approach, TM–IMC, using text mining and inductive matrix completion, for automated prediction of the gene ontology (GO) terms of the GPCR proteins. Large-scale benchmark tests show that inductive matrix completion models contribute to GPCR-GO association prediction for both molecular function and biological process aspects. Moreover, our detailed data analysis shows that information extracted from GPCR-associated literature indeed contributes to the prediction of GPCR–GO associations. The study demonstrated a new avenue to enhance the accuracy of GPCR functionannotation through the combination of text mining and induction matrixcompletion over baseline methods in critical assessment of proteinfunction annotation algorithms and literature-based GO annotationmethods. Source codes of TM–IMC and the involved datasets canbe freely downloaded from for academic purposes.
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