A196 A COMPARISON OF LIVER FIBROSIS AND SIMPLE STEATOSIS ASSESSMENT USING GADOXETIC-ACID ENHANCED MRI WITH MR ELASTOGRAPHY AND MRI FAT FRACTION

摘要

BackgroundNon-alcoholic fatty liver disease (NAFLD) has become a pandemic, affecting up to 25% of the global population, with high incidence and prevalence in North America.¹ The spectrum of disease ranges from simple steatosis to steatohepatitis, with or without fibrosis (NASH). It is important to be able to diagnose patients with simple steatosis, but even more so to identify those with NASH given their increased risk of progression to cirrhosis. The gold standard for NASH diagnosis remains liver biopsy. However, given its invasive nature and recognized sampling error from heterogeneity of disease distribution, there has been an increase in the use of non-invasive techniques.² MRI-fat fraction (MR-FF) is validated for the assessment of hepatic steatosis³ and MR elastography (MRE) for fibrosis.⁴ MRE requires special hardware and software not readily available. As such, a more readily available imaging modality known as gadoxetic-acid enhanced MRI (GE-MRI), has shown to potentially differentiate simple steatosis from NASH.⁵