A114 SYSTEMATIC REVIEW AND META-ANALYSIS: ENDOSCOPIC AND HISTOLOGIC PLACEBO RATES IN INDUCTION AND MAINTENANCE TRIALS OF ULCERATIVE COLITIS

摘要

BackgroundTreatment targets in ulcerative colitis (UC) have evolved to include normalization of objective endoscopic and histologic endpoints. Minimizing the endoscopic and histologic placebo response and remission rate is critical for the conduct of efficient randomized controlled trials (RCTs) and development of new treatments, in order to maximize ability to detect differences between active comparator and placebo.