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Bacterial synthesis of metal nanoparticles as antimicrobials

机译:金属纳米颗粒作为抗菌剂的细菌合成

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摘要

Nanoscience, a pivotal field spanning multiple industries, including healthcare, focuses on nanomaterials characterized by their dimensions. These materials are synthesized through conventional chemical and physical methods, often involving costly and energy‐intensive processes. Alternatively, biogenic synthesis using bacteria, fungi, or plant extracts offers a potentially sustainable and non‐toxic approach for producing metal‐based nanoparticles (NP). This eco‐friendly synthesis approach not only reduces environmental impact but also enhances features of NP production due to the unique biochemistry of the biological systems. Recent advancements have shown that along with chemically synthesized NPs, biogenic NPs possess significant antimicrobial properties. The inherent biochemistry of bacteria enables the efficient conversion of metal salts into NPs through reduction processes, which are further stabilized by biomolecular capping layers that improve biocompatibility and functional properties. This mini review explores the use of bacteria to produce NPs with antimicrobial activities. Microbial technologies to produce NP antimicrobials have considerable potential to help address the antimicrobial resistance crisis, thus addressing critical health issues aligned with the United Nations Sustainability Goal #3 of good health and well‐being.
机译:纳米科学是一个跨越多个行业(包括医疗保健)的关键领域,专注于以尺寸为特征的纳米材料。这些材料是通过传统的化学和物理方法合成的,通常涉及昂贵且能源密集型的工艺。或者,使用细菌、真菌或植物提取物的生物合成为生产金属基纳米颗粒 (NP) 提供了一种潜在可持续且无毒的方法。这种环保的合成方法不仅减少了对环境的影响,而且由于生物系统独特的生物化学性质,还增强了 NP 生产的特点。最近的进展表明,与化学合成的 NP 一起,生物 NP 具有显着的抗菌特性。细菌固有的生物化学性质能够通过还原过程将金属盐有效地转化为 NP,并通过改善生物相容性和功能特性的生物分子覆盖层进一步稳定。这篇迷你综述探讨了使用细菌生产具有抗菌活性的 NP。生产 NP 抗菌剂的微生物技术具有相当大的潜力,可以帮助解决抗菌素耐药性危机,从而解决与联合国可持续发展目标 #3 的良好健康和福祉相一致的关键健康问题。

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