Background: Left atrial (LA) assessment is an important marker of adverse cardiovascular outcomes. Cardiovascular magnetic resonance (CMR) accurately quantifies LA volume and function based on biplane long-axis imaging. We aimed to validate single-plane-derived LA indices against the biplane method to simplify the post-processing of cine CMR. Methods: In this study, 100 patients from Leeds Teaching Hospitals were used as the derivation cohort. Bias correction for the single plane method was applied and subsequently validated in 79 subjects. Results: There were significant differences between the biplane and single plane mean LA maximum and minimum volumes and LA ejection fraction (EF) (all p < 0.01). After correcting for biases in the validation cohort, significant correlations in all LA indices were observed (0.89 to 0.98). The area under the curve (AUC) for the single plane to predict biplane cutoffs of LA maximum volume ≥ 112 mL was 0.97, LA minimum volume ≥ 44 mL was 0.99, LA stroke volume (SV) ≤ 21 mL was 1, and LA EF ≤ 46% was 1, (all p < 0.001). Conclusions: LA volumetric and functional assessment by the single plane method has a systematic bias compared to the biplane method. After bias correction, single plane LA volume and function are comparable to the biplane method.
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机译：背景： 左心房 （LA） 评估是不良心血管结局的重要标志。心血管磁共振 （CMR） 基于双平面长轴成像准确量化 LA 体积和功能。我们旨在针对双平面方法验证单平面衍生的 LA 指数，以简化电影 CMR 的后处理。方法： 在本研究中，使用来自利兹教学医院的 100 例患者作为衍生队列。对单平面方法应用偏倚校正，随后在 79 名受试者中进行了验证。结果： 双平面和单平面平均 LA 最大和最小体积以及 LA 射血分数 （EF） 之间存在显着差异 （均 p < 0.01）。在校正验证队列中的偏倚后，观察到所有 LA 指数的显着相关性 （0.89 至 0.98）。单平面预测 LA 最大体积≥ 112 mL 的双平面截断值的曲线下面积 （AUC） 为 0.97，≥ 44 mL 的 LA 最小体积为 0.99，LA 每搏输出量 （SV） ≤ 21 mL 为 1，LA EF ≤ 46% 为 1，（均 p < 0.001）。结论： 与双平面方法相比，单平面方法的 LA 体积和功能评估具有系统偏倚。偏置校正后，单平面 LA 体积和功能与双平面方法相当。
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