Background: Deep vitrectomy is one of the most frequently performed ophthalmic procedures. Postoperative pain is a common complaint among patients. Consequently, we investigated whether metoclopramide and aminophylline could decrease pain intensity following deep vitrectomy. Methods: This double-blinded clinical trial study that was approved by the Ethical Committee of Isfahan University of Medical Sciences (IR.MUI.REC.1396.3.217) (Thesis Reg. number: 396217) and registered at the Iranian Registry of Clinical Trials (IRCT) (Reg. number: IRCT20170716035104N5, available at https://www.irct.ir/trial/59146) aimed to evaluate 105 patients who were candidates for deep vitrectomy. They were randomly assigned into three groups: metoclopramide (received 0.1 mg/kg diluted in 10 ml of normal saline), aminophylline (received 4 mg/kg diluted in 10 ml of normal saline), and placebo (received 10 ml of normal saline). Postoperative pain was evaluated in all groups. Results: The postoperative pain levels of the three groups differed significantly from the start of the recovery to 30 minutes, 60 minutes, 2 hours, and 4 hours postoperatively, with metoclopramide and aminophylline groups experiencing less postoperative pain than the placebo group. Moreover, there was a significant difference between the groups regarding patient satisfaction (P<0.05). Conclusion: Both metoclopramide and aminophylline significantly reduce postoperative pain after deep vitrectomy, although metoclopramide has a greater effect.
展开▼
机译：背景： 玻璃体深层切除术是最常用的眼科手术之一。术后疼痛是患者的常见抱怨。因此，我们研究了甲氧氯普胺和氨茶碱是否可以降低玻璃体深部切除术后的疼痛强度。方法： 这项双盲临床试验研究获得了伊斯法罕医科大学伦理委员会 （IR.梅。REC.1396.3.217）（论文注册号：396217）并在伊朗临床试验注册处 （IRCT） 注册（注册号：IRCT20170716035104N5，可在 https://www.irct.ir/trial/59146 获得）旨在评估 105 名适合玻璃体深层切除术的患者。他们被随机分为三组：甲氧氯普胺 （接受 0.1 mg/kg 稀释于 10 ml 生理盐水）、氨茶碱 （接受 4 mg/kg 稀释于 10 ml 生理盐水）和安慰剂 （接受 10 ml 生理盐水）。评估所有组的术后疼痛。结果： 3 组术后疼痛程度从恢复开始到术后 30 min 、 60 min、2 h 和 4 h 差异显著，甲氧氯普胺组和氨茶碱组术后疼痛程度低于安慰剂组。此外，两组患者满意度存在显著差异 （P<0.05）。结论： 甲氧氯普胺和氨茶碱均显著减轻玻璃体深部切除术后的术后疼痛，但甲氧氯普胺效果更大。
展开▼
