The gasdermins (GSDM), a family of pore-forming proteins, consist of gasdermin A (GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), gasdermin D (GSDMD), gasdermin E (GSDME) and DFNB59 (Pejvakin (PJVK)) in humans. These proteins play an important role in pyroptosis. Among them, GSDMD is the most extensively studied protein and is identified as the executioner of pyroptosis. Other family members have also been implicated in certain cancers. As a unique form of programmed cell death, pyroptosis is closely related to tumor progression, and the inflammasome, an innate immune mechanism that induces inflammation and pyroptosis. In this review, we explore the current developments of pyroptosis, the inflammasome, and especially we review the gasdermin family members and their role in inducing pyroptosis and the possible therapeutic values in antitumor effects.
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机译：gasdermins （GSDM） 是一个成孔蛋白家族，在人类中由 gasdermin A （GSDMA）、gasdermin B （GSDMB）、gasdermin C （GSDMC）、gasdermin D （GSDMD）、gasdermin E （GSDME） 和 DFNB59 （Pejvakin （PJVK）） 组成。这些蛋白质在焦亡中起重要作用。其中，GSDMD 是研究最广泛的蛋白质，被确定为焦亡的执行者。其他家庭成员也与某些癌症有关。作为一种独特的程序性细胞死亡形式，焦亡与肿瘤进展和炎症小体密切相关，炎性小体是一种诱导炎症和焦亡的先天免疫机制。在这篇综述中，我们探讨了炎症小体焦亡的当前发展，特别是我们回顾了 gasdermin 家族成员及其在诱导焦亡中的作用以及抗肿瘤作用中可能的治疗价值。
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