The cAMP effector EPAC activates Elk1 transcription factor in prostate smooth muscle and is a minor regulator of α1-adrenergic contraction

摘要

BackgroundProstate smooth muscle tone is regulated by α1-adrenoceptor-induced contraction and cAMP-mediated relaxation. EPAC is an effector of cAMP, being involved in smooth muscle relaxation and cell cycle control outside the lower urinary tract. Here, we investigated the expression and function of EPAC in human prostate tissues from patients undergoing radical prostatectomy.