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Different perspectives on translational genomics in personalized medicine

机译:个性化医疗中转化基因组学的不同观点

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摘要

Personalized medicine is a relatively new and interesting concept in the medical and healthcare industries. New approaches in current research have supported the search for biomarkers, based on the genomic, epigenomic and proteomic profile of individuals, using new technological tools. This perspective involves the potential to determine optimal medical interventions and provide the optimal benefit-risk balance for treatment, whilst it also takes a patient’s personal situation into consideration. Translational genomics, a subfield of personalized medicine, is changing medical practice, by facilitating clinical or non-clinical screening tests, informing diagnoses and therapeutics, and routinely offering personalized health-risk assessments and personalized treatments. Further research into translational genomics will play a critical role in creating a new approach to cancer, pharmacogenomics, and women’s health. Our current knowledge may be used to develop new solutions that can be used to minimize, improve, manage, and delay the symptoms of diseases in real-time and maintain a healthy lifestyle. In this review, we define and discuss the current status of translational genomics in some special areas including integration into research and health care.
机译:个性化医疗在医疗和保健行业是一个相对较新且有趣的概念。当前研究中的新方法支持使用新技术工具,根据个体的基因组、表观基因组和蛋白质组学特征寻找生物标志物。这种观点涉及确定最佳医疗干预并为治疗提供最佳收益-风险平衡的潜力,同时也考虑了患者的个人情况。转化基因组学是个性化医学的一个子领域,通过促进临床或非临床筛查测试、为诊断和治疗提供信息以及定期提供个性化的健康风险评估和个性化治疗,正在改变医疗实践。对转化基因组学的进一步研究将在创建癌症、药物基因组学和女性健康的新方法方面发挥关键作用。我们目前的知识可用于开发新的解决方案,这些解决方案可用于实时减少、改善、管理和延缓疾病症状,并保持健康的生活方式。在这篇综述中,我们定义并讨论了转化基因组学在一些特殊领域的现状,包括融入研究和医疗保健。

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